Comparison between prostaglandin in gingival inflammation in diabetics and non-diabetics

ABSTRACT

In this study, the level of prostaglandin in gingival tissue extract obtained form diabetic and non-diabetic individuals suffering from severe gingival inflammation was estimated using prostagl and ins radioimmunoassay technique. The patients were classified into 3 groups [non-diabetics, non-insulin dependent diabetic patients and insulin-dependent diabetic patients], all had the same degree of gingival inflammation as assessed clinically by [GI] and histopathologically. All patients were subjected to full mouth debridement one month prior to any procedure. Tissue biopsies were obtained for histopathological examinations and for measuring level of PG in tissue extract. The results demonstrated a highly significant increase in PGs in diabetic patients comparing with non-diabetics, also clinical evaluations revealed a significant increase in gingival bleeding in diabetics. Chronic hyperglycemia may be responsible for exaggerated production of PGs and for microvascular changes of gingival tissue