Effect of dietary supplementation of active EPA-30 on the phospholipid metabolism in the rat liver

ABSTRACT

To explore the useness of fish oil [active EPA-30] as a source of eicosapentenoic acid [EPA, 20 5 n-3], the studies were performed on a total of 120 rats, divided into 2 equal groups. The results showed that, the young rats fed on pig-fat [n-3 fatty acids deficient diets] had a drastic decrease in the amount of phosphatidylethanolamine [PE] and omega-3 polyunsaturated fatty acids [eicosapentenoic, EPA, 20 5 n-3 and docosahexenoic, DHA, 22 6 n-3] and compensatory increase of phosphotidylcholine, saturated fatty acids and n-6 polyunsaturated fatty acids in the phospholipids of their liver. In contrast, the rats fed on active EPA-30 has large amounts of PE and complementary enrichment with polyunsaturated fatty acids. While the old rats, supplemented with active EPA-30 had lowest amounts of PE and there is no any significant changes in the phospholipid fatty acid compositions