Creatine kinase, lactate dehydrogenase, cortisol and ACTH in chronic renal failure and kidney transplanted patients

ABSTRACT

Creatine kinase [CPK], lactate dehydrogenase [LDH], cortisol and adrenocorticotropic hormone [ACTH] were evaluated in 75 subjects, classified into 3 groups Normal healthy 25 cases as a control group [I], chronic renal failure patients [CRF] 25 cases group [II], and renal transplanted patients [RT] 25 cases group [III]. The mean level of serum CPK activity in control group was 98.76 +/- 26.67 U/L, while in chronic renal failure patients and renal transplanted subjects the mean level were 205.80 +/- 37.12 U/L and 173.91 +/- 39.36 U/L, respectively, these data were significantly higher than the control group. The mean level of serum LDH activity in control group was 313.14 +/- 39.37 U/L, while in chronic renal failure and renal transplanted subjects the mean level of serum LDH were increased significantly to be 389.18 +/- 52.40 U/L and 387.35 +/- 52.35 U/L, respectively. The mean level of serum cortisol concentration in control group was 112.67 +/- 35.92 ng/ml, while in chronic renal failure patients and renal transplanted subjects the mean of serum cortisol concentration increased significantly to be 227.36 +/- 52.04 ng/ml and 165.52 +/- 44.34 ng/ml, respectively. The mean level of plasma ACTH concentration in control group was found to be 8.43 +/- 5.15 pg/ml, while in renal transplantation patients ACTH increased significantly to be 16.9 +/- 10 pg/ml than the control group