Effect of non-antibiotic penicillin derivatives on intestine and serum lipids in lead intoxicated rats

ABSTRACT

Seventy-seven male albino rats were toxicated with lead for two months. Two non-antibiotic penicillin derivatives were prepared as a trial to use them to detoxicate lead toxicity. The body weight of all animal groups under investigation increased, except orally administrated lead. At the end of the experimental periods, rats were killed and their blood was collected, serum was separated and small intestine was removed. The mean lead level in small intestine and serum increased when compared to control, but the prepared compounds succeeded to decrease these results. Compound II showed better results than compound I when it succeeded to decrease the concentration of lead. Total lipids, cholesterol, phospholipids, triglycerides and free fatty acids decreased in small intestine, whereas, they increased in serum. The prepared compounds succeeded in decreasing or increasing the values of the parameter investigated to reach nearly the values of control group. The gas liquid chromatographic analysis was used to investigate the individual free fatty acids of lead intoxicated rats