Synthesis of pyrazolo [3,4-b] pyridine derivatives

ABSTRACT

The reaction of 3-amino-5-pyrazolones with 1, 3-dicarbonyl compounds has been shown to give either pyrazolo[l,5-a] pyrimidine or pyrazolo [3,4-b] pyridines depending on the conditions employed. The pyrazolo [3,4-b] pyridines were reported to be valuable from both the pharmacological and antimicrobial view points. Consequently, the present work comprised the investigation of the reaction of l-phenyl-3-amino-5-pyrazolone [I] with ethyl acetylpyruvate [II] aiming to synthesise pyrazolo [3,4-b] pyridine derivatives of biological interest