Extranodal stage le Non Hodgkin's Lymphoma of paranasal sinuses: a report of 7 cases and the review of literature

Study of clinicopathological behaviour of Paranasal Sinus Lymphoma in a single institution. Retrospective study of 7 patients of Clinical Stage le Non-hodgkins Lymphoma treated between 1990-1994. Department of Medical Oncology and Radiation Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi. India. 7 patients with Clinical Stage le Non-Hosgkin's lymphoma attending Out patient department. Main outcome measures: Age, Clinical presentation, Histology. Response to treatment, Patter on relapse, Leptomentingeal spread, Disease free survival. Complete response after 3 cycles of chemotherapy was noted in 4 patients; Of the 3 patients who had residual disease following 3 cycles of chemotherapy, 2 more achieved complete response with radiation therapy. One patient had progressive disease. Two patients relapsed in central nervous system within 6 months of completion of therapy. Both had partial response to chemotherapy and they also recurred loco regionally. Four patients are alive for +26, +38, +24, +28 months. We conclude that paranasal sinus non-Hodgkin's lymphoma should be treated aggressively with combination chemotherapy and radiotherapy. Their response to initial chemotherapy should be monitored carefully; Complete response to initial 3 cycles of chemotherapy predicted better outcome. Central nervous system prophylaxis with intrathecal chemotherapy and cranial irradiation should be offered to all