Pharmacokinetic profile of pipemidic acid in normal and nephritic rats

ABSTRACT

The pharmacokinetic profile, tissue distribution and residual content of pipemidic acid were studied in normal and nephritic rats. The maximum serum concentration was reached after 1 hour in both normal and nephritic rats following oral administration of 50 mg/kg b. wt. Lower serum concentration were detected in nephritic rats at corresponding time intervals as compared with healthy ones. Following the intravenous injection of pipemidic acid, the resulting curves were best fitted to follow two compartment open model. The drug was highly distributed in all tested tissues and completely disappeared from all tissues after 9 and 15 days in healthy and nephritic rats following its oral administration in a dose of 50 mg/kg b. wt. twice daily for 5 successive days