Testing a new formulation of ivermectin [ivomec pour-on and bolus] as broad spectrum parasiticide

ABSTRACT

The new formulations of invermectin [MSD AGVET], Ivomec pour-on used for cattle in a dose of 1 ml/10 kg b. wt. and Ivomec bolus used per mouth for sheep in a dose of 0.5 bolus for each 25 kg b. wt. [10 mg/50 kg b. wt.], were tested for control of natural infestation by gastrointestinal nematode parasites [GIN] in cattle and sheep as well as for treatment of mange infection in sheep. The two drugs showed promising results in the form of freeing the treated animals from the target parasites by a percentage varies from 60 to 100% [in a mean of 85%] and decrease in the mean egg/g feces [EPGF] from 695 on day zero to 15 EPGF on 35th day post-treatment [dpt] for the pour-on form and 80-100% in sheep GIN with marked decrease in the mean total EPGF from 765 on day zero to 8.3 EPGF in 28th dpt. The bolus form succeeded in eradication of mange from the treated sheep by an efficacy varying from 82.69 to 100%. The two drugs showed absolute protection for the treated animals till 21st dpt and very marked decrease in EPGF even for the still positive animals till end of the observation period. Cooperia, Nematodierus and Trichuris species appear slightly less Susceptible to be used dose of the drugs than the other gastrointestinal nematode larvae