Teratogenicity and effects on male fertility of thiodicarb insecticide in albino rats

ABSTRACT

Thiodicarb [larvin] was administered orally to pregnant female albino rats in doses of 3.98 and 1.99 mg/kg b. wt. daily at the organogenisis period [6-15th day of gestation]. The administered doses resulted in decrease in number of implantation sites and survived feti and increased number of resorbed feti. The obtained results showed many visceral malformations [retarded growth, dilated cerebral ventricles, absence of thymus, atrophy of lungs and heart and dilated renal pelvis]. Skeletal examination showed incomplete ossification of the skull, reduction in number of caudal and sacral vertebrae, absence of some sternbrae, incomplete pelvic girdle, fused tibia and fibula and absence of phalanges. In male albino rats, oral administration of 3.98 and 1.99 mg/kg b. wt. for 65 days, resulted in decrease in sperm cell count, sperm motility and of live/dead sperms ratios