Insulin resistance syndrome in pre-eclampsia

ABSTRACT

This study is designed to determine if hyperinsulinaemia, hypertension, hypertriglyceridaemia, and low level of high density lipoprotein 2[HDL[2]] cholestrol are present in women with non-proteinuric hypertension or pre-eclampsia. In 40 cases pregnancy - induced hypertension [20 non-proteinuric hypertension and 20 pre-eclampsia] and 20 healthy pregnant women [control group]. Serum concentration of insulin, triglyceride and HDL2 cholesterol were measured It has been found that insulin and triglyceride were significantly increased while HDL2 cholesterol was significantly decreased in both non-proteinuric hypertension and Pre-eclampsia as copmared with the control group. There was no significant difference in serum concentrations of insulin, triglyceride or HDL2 cholesterol between both groups of pregnancy induced hypertension. It has been concluded that the metabolic characteristics of insulin resistance syndrome are present in non-proteinuric hypertension, but they are not aggravated in Pre-eclampsia. Although these metabolic perturbations may be related to the pathogenesis of Pre-eclampsia, it is propable that Pre-eclampsia has characteristic serum factor[s] responsible for the pathopysiological changes in this symlrome