New pyridazinedione derivatives: synthesis and antimicrobial activity

ABSTRACT

Various substituted and unsubstituted pyridazine-3, 6-diones were prepared in a good yield via the reaction of p-nitrobenzoic acid hydrazide with diacyltartaric acid anhydride, maleic or phthalic acid anhydride [I-IV]. Then, each pyridazinone derivative was condensed with urea, thiourea or hydrazine to afford the corresponding pyridazinotriazine or triazolopyridazine derivatives [V-XVI], respectively. The spectral properties of the products were studied and the antimicrobial activity was evaluated