Effect of a new triazinoaminopiperidine derivative [S9788] on the binding of vinceistine to and 1-acid glycoprotein: implication in multidrug resistance phenomena
Assiut Medical Journal. 1997; 21 (3): 109-118
in English
| IMEMR
| ID: emr-44102
ABSTRACT
Multidrug resistance [MDR] was circumvented by a large number of compounds including verapamil and a newly synthesized triazinoaminopiperidine derivative S9788 [Servier 9788]. S9788 was found to overcome multidrug resistance both in vitro and in vivo. The mode of action of these chemosensitizers is thought to involve interaction on P-glycoprotein, a membrane-bound efflux transport protein for cytotoxic drugs. On the other hand, verapamil binds strongly to alpha 1-acid glycoprotein [AGP] in serum or solutions and AGP can modulate the chemosensitizing action of verapamil in MDR in vitro. The interaction of S9788 with [3H] vincristine was measured at binding sites on alpha 1-acid glycoprotein in vitro using equilibrium dialysis [Dianorm] and clinically relevant concentrations of ligands and protein
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Piperidines
/
Triazenes
/
Orosomucoid
/
Verapamil
/
Drug Resistance, Multiple
Language:
English
Journal:
Assiut Med. J.
Year:
1997
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