Pathogenetic and prognostic significance of circulating immuno complexes, immunoglobulins and complement-4 in childhood itp
Assiut Medical Journal. 1997; 21 (4): 185-194
in English
| IMEMR
| ID: emr-44122
ABSTRACT
In order to evaluate the role of circulating immune complexes [CIC], immunoglobulins and complement-4 [C4] in the pathogenesis and the prognosis of childhood idiopathic thrombocytopenic purpura [ITP]; 45 children with ITP [35 acute ITP, and 10 chronic ITP] aged 2-13 years as well as 15 healthy children as controls were studied. It was concluded that circulating immune complexes, immunoglobulins G and M and C4 had a role in the pathogenesis of ITP. Factors which might predict chronicity of ITP were older age at onset >7 years, preceding illness >4 weeks, lymphocyte count <20%, polymorphs count >60%, megakaryocyte count 2-6% and CIC level >60% I
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Prognosis
/
Complement C4
/
Immunoglobulins
/
Child
/
Purpura, Thrombocytopenic, Idiopathic
/
Antigen-Antibody Complex
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Assiut Med. J.
Year:
1997
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