Serum laminin, hyaluronan, and procollagen Ill: diagnostic and prognostic markers in liver cirrhosis

ABSTRACT

This work was carried out on 30 patients with liver cirrhosis and ten normal subjects, age and sex matched, served as controls. The patients were classified according the Child and Turcotte [Child A n=16 Child B n=6. Child C n=8]. Serum laminin, hyaluronan, and type III procollagen were determined to evaluate their role as diagnostic and prognostic markers in inducing major severe complications in liver cirrhosis. The serum laminin, hyaluronan, and type III procollagen were significantly elevated in liver cirrhosis patients compared to controls and this elevation increased with more advanced Child stage. Also there was a positive correlation, between these parameters and esophageal varices and the occurrence of major complications in liver cirrhosis. We can concluded that serum laminin, hyaluronan and procollagen III are useful, and noninvasive parameters in patients with liver cirrhosis and as clinically important markers in addition to Child classification for deterioration of liver cirrhosis