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ABSTRACT
In this study, 240 adult healthy albino rats of both sexes were used. They were classified into control and drug-treated groups. Full thickness excised skin wounds were inflicted on the shaved dorsal aspect of the thoracic wall. The mean healing time, rate of wound contraction, the total and the saline soluble collagen concentrations in the healing wound area were measured. Loratadine did not significantly alter any of the wound healing parameters studied. Cimetidine has caused a statistically significant shortening of the mean healing time, acceleration of wound contraction rate, reduction of the total and increase in the saline soluble collagen concentration in the healing wound area 2 and 3 weeks post-wounding
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Index: IMEMR (Eastern Mediterranean) Main subject: Rats / Skin / Cimetidine / Loratadine / Histamine H1 Antagonists / Histamine H2 Antagonists Limits: Animals Language: English Journal: Bull. Alex. Fac. Med. Year: 1997

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Index: IMEMR (Eastern Mediterranean) Main subject: Rats / Skin / Cimetidine / Loratadine / Histamine H1 Antagonists / Histamine H2 Antagonists Limits: Animals Language: English Journal: Bull. Alex. Fac. Med. Year: 1997