Ondansetron in the prevention of postoperative nausea and vomiting in gynaecological surgery

ABSTRACT

In a double blind randomized study, we compared the prophylactic antiemetic effect of Ondansetron, a 5 HT3 receptor antagonist with that of placebo on postoperative nausea and vomiting in 92 patients undergoing general anaesthesia for gynaecological surgery. The patients received either 4 mg bolus ondansetron or placebo I.V immediately after induction of general anaesthesia. Postoperative nausea and vomiting were assessed for 24 hrs. The incidence of vomiting was 10.86% in the ondansetron group and 34.78% in the placebo group [p < 0.05]. There was no significant difference in the incidence of nausea between the two groups