Some pharmacological effects of captopril, Lisinopril and perindopril in experimental hypertensive rats

ABSTRACT

The present work is an experimental study of the effects of chronic administration [two and four weeks] of three angiotensin converting enzyme inhibitors [ACEIs] [captopril, lisinopril and perindopril] on arterial blood pressure [BP], glomerular filtration rate [GFR], renal plasma flow [RPF], serum electrolytes [Na+ and K+], serum glucose and serum lipids [cholesterol, HDL and LDL] in experimental hypertensive rats. Hypertension had been induced in rats by ligation of the left renal artery. The three test drugs produced reduction in BP, captopril showed the less effect. GFR decreased, while RPF increased with the three drugs, perindopril produced the most marked increase in RPF. Also, the three drugs produced decrease in serum Na+ with increase in K+ level. Fasting serum glucose and serum lipids showed no change with the three drugs. It can be concluded that captopril, lisinopril and perindopril are recommended in hypertension, especially with that associated with the decreased RPF, diabetes and hyperlipidemia