Reactions of 3-hydroxycoumarin derivatives with amines and hydrazines and their antibacterial activity

ABSTRACT

Fusion of 6-bromo, 6,8-dibromo and 6-nitro-3-hydroxycoumarin with primary and secondary amines led to the formation of 3-aminocoumarin derivatives. Reaction of 3-hydroxycoumarin derivatives with hydrazine hydrate yielded 3-hydroazinocoumarin derivatives. Heating alpha- phenylhydrazino-beta-2-hydroxy-5-nitrocinnamic acid phenylhydrazide with acetic anhydride and hydrochloric acid gave 6-nitro-3-phenylhydrazinocoumarin