Effect of L- carnitine on lipid peroxidation in gentamicin induced nephrotoxicity in rats

ABSTRACT

In order to evaluate a possible new protective effect of 1- carnitine in gentamicin induced nephrotoxicity, groups of rats treated either with saline, I- carnitine, gentamicin alone or gentamicin and 1- carnitiric in combination. The results showed that gentamicin produces high plasma urea, creatinine and malondialdehyde [MDA] which reached to the level of significance when compared with saline treated group. The morphological changes are of degeneration of proximal convoluted tubules. L- carnitine attenuated the biochemical and morphological changes induced by gentamicin. It is concluded that 1- carnitine afforded renal protection via prevention of further accumulation of lipid which stimulates the lipid peroxidation process