Agenesis of the penis: report of two cases and review of the literature

ABSTRACT

Two cases of congenital penile agenesis, one associated with other urogenital anomalies and cleft lip and the other associated with imperforate anus and limb deformities are presented. The results of post mortem examination of this rare condition are reported on one case with correlation of the findings to the embryogenic development of the genito- urinary organs. Apenia [congenital absence of the penis] is an exceedingly rare congenital anomaly estimated to occur once in 30 million male births[1]. Since the review of the world literature by Richart and Benirschke in 1960[2] in which they collected 27 cases, an additional 25 cases has been reported. Many of these cases are associated with other anomalies. We report here two cases of agenesis of the penis, one was associated with agenesis of the prostate and seminal vesicles and hydronephrosis as well as cleft lip, with autopsy findings, and the other was associated with imperforate anus and limb deformities