Therapy related acute myeloblastic leukemia following gestational trophoblastic tumor: Possible role of high cumulative dose of etoposide
KMJ-Kuwait Medical Journal. 1997; 29 (4): 423-426
in English
| IMEMR
| ID: emr-45312
ABSTRACT
The development of secondary acute myeloblastic leukemia [sAML] following chemotherapy of a gestational trophoblastic tumor [GTT] is rare. Alkylating drugs are known leukemogenic agents and epipodophyllotoxins have been implicated in the causation of a distinct subset of sAML. We report a case of s AML following treatment of a gestational trophoblastic tumor with multiagent chemotherapy including alkylating agents and a high dose of etoposide. The leukemia was characterized as myelomonocytic leukemia [FAB- M4] with a normal chromosomal pattern and without any preceding myelodysplastic phase. The leukemia developed 3 years and 6 months after the first etoposide exposure. Continuous exposure to etoposide following administration of other cytotoxic drugs including alkylating drugs may increase the risk of sAML
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Leukemia, Myeloid, Acute
/
Trophoblastic Neoplasms
/
Antineoplastic Agents, Alkylating
/
Etoposide
Type of study:
Case report
Limits:
Female
/
Humans
Language:
English
Journal:
Kuwait Med. J.
Year:
1997
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