Helicobacter pylori infection associated with gastroesophageal reflux in patients with bronchial asthma: effect of eradication

ABSTRACT

This study explored the effect of Helicobacter pylori [Hp] eradication on chronic asthma patients with GERD associated with Hp infection. Forty-five adult patients with chronic moderate to severe asthma and GERD associated Hp infection were randomly assigned to three groups. Group I [triple therapy group] [n = 15] received 1000 mg amoxicillin bid and clarithromycin 500 mg bid for two weeks and omeprazole 20 mg bid for three months, Group II [omeprazole group] [n = 15] received omeprazole 20 mg bid for three months and Group III [control] [n = 15] received placebo for three months. Observation continued for three months after drug trial phase [wash out phase]. It was concluded that Hp has significant role in chronic asthma patients associated with GERD and its eradication results in long term improvement of both asthma and GERD