Mycobacteria as immunogens: development of expression vectors for use in multiple mycobacterial species
Medical Principles and Practice. 1997; 6 (2): 91-96
in English
| IMEMR
| ID: emr-45955
ABSTRACT
The development of gene transfer systems that are applicable to a wide variety of mycobacterial hosts will provide an important tool for the generation of recombinant mycobacterial candidate vaccines. Here we describe the construction of a series of hygromycin-based expression vectors that enable the expression of foreign antigens in Mycobacterium vaccae, a candidate mycobacterial delivery host. These vectors may be useful in exploring effective delivery of heterologous molecules by a variety of different mycobacterial hosts
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Hygromycin B
/
Gene Transfer Techniques
/
Escherichia coli
/
Genetic Vectors
/
Mycobacterium tuberculosis
Language:
English
Journal:
Med. Princ. Pract.
Year:
1997
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