study of the genotoxic effects of vinyl chloride in exposed workers

ABSTRACT

The study was carried out on 20 exposed workers to VC for 0.5 to 12 years and10 healthy controls. Analysis of chromosome aberration [CA] and mitotic index[MI] were performed. No significant difference was found as regards the agesof studied groups. A statistically significant increase in the frequency ofCA was observed in long and short term-exposed workers than the controls. Inaddition, there was significant correlation between total Ca and duration ofexposure to VC [r=0.779]. A negative significant correlation was foundbetween MI and duration of exposure [r=-0.728]. The study suggests that CAand MI could be useful and sensitive indicators of VC induced genetic damage. The study also proved that short exposure is as effective as long exposure toVC in producing chromosome damage and significant reduction in MI. Therefore,there is a continuous need to improve safety, environmental and sanitaryconditions in plastic factories