Nalbuperine for relief of labour pain in primiparous women

ABSTRACT

The analgesic efficacy and safety of Butorphanol 2mg [BUT-2] and nalbuphine hydrochloride 15mg [NAL-15] administered intramuscularly were compared in randomized, double blind clinical trail in sixty pregnant women with labour pain. Pain relief was measured by a 4 point verbal rating scale, 10,20,30,45 and 60 minutes after administration of drug. The average total pain relief [TOTPAR] score within first hour was 1.8 with BUT-2 and 1.7 with NAL-15 [P < 0.05]. NAL-15 was associated with higher frequency of adverse events and significantly lower respiratory rate in neonates. The results indicate] that BUT-2 is as effective as NAL-15 but has a superior safety profile