effect of extracorporeal shock wave lithotripsy [ESWL] on angiotensin I, N-acetyl-B-glucosaminidase, urinary marker proteins, parathyroid hormone, pancreatic amylase and muscle injury enzyme markers

ABSTRACT

To detect the source of relevant acute intrarenal side effects after extracorporeal shock wave lithotripsy [ESWL], urinary excretion of highly specific marker proteins [alpha 1 and beta 2 microglobulin], as well as tubular enzyme N-acetyl-beta-D glucosaminidase [NAG] were analyzed before and after ESWL. A highly significant increase in urinary marker proteins [alpha 1 M and beta 2 M] and urinary enzyme NAG were recognized immediately following ESWL. Alpha 1 M and NAG returned to their pre-ESWL levels but beta 2 M remained high till day 30. Plasma renin activity-PRA [angiotensin I] was highly significantly elevated immediately after ESWL and remained high after 1 month. The parathyroid hormone [PTH], CK-MB were highly significant elevated. Gamma glutamyl transferase [GGT], alanine aminotransferase [ALT], aspartate aminotransferase[AST], alkaline phosphatase[ALP] and pancreatic amylase were significantly higher than normal immediately after ESWL but all to their pre-ESWL values after 1 month