Cisplatin induced toxicity and the modulating effect of antioxidants
New Egyptian Journal of Medicine [The]. 1997; 16 (5): 413-420
in English
| IMEMR
| ID: emr-46226
ABSTRACT
This study was conducted on 120 albino rats divided into 8 equal groups. The study showed that group V [cisplatin group] caused highly significant increases in blood urea nitrogen [BUN], serum creatinine, total cholesterol, triglycerides, total bilirubin, direct bilirubin, alkaline phosphatase, serum glutamic pyruvic transaminase [SGPT], serum glutamic oxaloacetic transaminase [SGOT] together with highly significant reductions in serum electrolytes [serum calcium, Ca, serum potassium, K and serum sodium, Na], total proteins and albumin. Histopathological examination of kidney in group V showed tubular necrosis, focal cytoplasmic vacuolation and interstitial hemorrhages. Histopathological examination of liver in group V showed cloudy swelling of hepatocyte and sinusoidal dilatation
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Acetylcysteine
/
Rats
/
Vitamin E
/
Toxicity Tests
/
Antineoplastic Agents
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
New Egypt. J. Med.
Year:
1997
Similar
MEDLINE
...
LILACS
LIS