Correlation between serum procollagen-IC end terminal peptide [PCICP] levels and bone mineral density measurements in hormone treated and untreated postmenopausal women

ABSTRACT

This study aimed to compare bone mineral density measurements [BMD] and serum procollagen-1C end terminal peptide [PC1CP] level in untreated and hormone treated postmenopausal women. A cross-sectional study compared the biophysical BMD and biochemical PC1CP parameters in a group of untreated postmenopausal women [n = 50] with a group of postmenopausal women on hormone replacement therapy [HRT] [n = 35]. The results showed that the untreated postmenopausal women had higher osteoblastic and osteoclastic activity than postmenopausal women on HRT. PC1CP was 11.3% lower in the women on HRT compared with controls. The difference in bone density of L2-L4 between the two groups was 16.1%. So, it was concluded that postmenopausal women receiving HRT readjusted their bone remodeling so that although osteoblastic function was reduced, there was much greater deduction in osteoclastic function which resulted in an overall higher bone mass observed in the BMD of women on HRT