Soluble interleukin-2 receptor [sIL-2R] in some hematologic malignancies

ABSTRACT

The aim of this study was to evaluate serum levels of sIL-2R in some of the hematologic malignancies and to find out if it could be a predictive marker of tumor burden and response to therapy. The mean value of sIL-2R in ALL was significantly elevated than in the controls. It was also significantly high in the patients with activity as compared with those at remission. Also, the mean value of sIL-2R in NHL was significantly elevated compared with the controls. Newly diagnosed cases had a high mean serum value of sIL-2R compared with those under treatment and a more significant elevation in comparison with the cases at remission. Also, patients under treatment showed a significantly higher mean serum value of sIL-2R than patients at remission. In patients with HL the mean value of sIL-2R was significantly elevated as compared with the controls. Newly diagnosed cases with HL had a significantly high mean serum value of sIL-2R as compared with patients under treatment and at remission. Also, patients under treatment showed a significantly high mean serum value of sIL-2R compared with those at remission