Childhood nephrotic syndrome in Pakistan: clinical features and response to steroid therapy

ABSTRACT

Hundred children with nephritic syndrome [NS] were seen at Paediatric Department, Services Hospital, Lahore from March 1993 to August 1994. All were treated according to the protocol of NS in international study for kidney diseases in children [ISKDC]. 93.75% responded initially to corticosteroids whereas the remaining 6.25% were resistant. Out of those who initially responded 73.75% relapsed. All five resistant cases were treated with cyclophosphamide. Four achieved complete remission and one patient did not respond. This study revealed that majority have steroid responsive NS. i.e. minimal change diseases