Prevalence of helicobacter pylori in 156 consecutive patients with dyspepsia in the interior of Sindh, Pakistan

ABSTRACT

To observe the prevalence of Helicobacter Pylori in patients with dyspepsia. Design: Prospective and Retrospective study of 156 patients suffering from dyspepsia. Setting: Surgical out patients department and Surgical Wards of Peoples Medical College Hospital, Nawabshah. Subjects: 156 cases of dyspepsia with different age groups from 16 to 60 years. Main outcome measures: Barium Meal examination, upper gastrointestinal endoscopy, three endoscopy biopsies from gastric antrum for rapid urease test and Histopathological examination for detection of Helicobacter pylori. In 102 [65.38%] of these patients, the histology specimens showed Helicobacter pylori in 88% of patients with duodenal ulcer, 85% of patients with gastric ulcer, 80% of patients with gastric erosion and duodenitis, and 63% patients with gastritis. The urease test was positive at six hours in 82 [52.56%] of these 156 patients. The Urease test was positive in 70% of each group of patients with endoscopic findings of gastric erosions, gastric ulcer and duodenal ulcer and duodenal erosions. The Helicobacter pylori does play a role in peptic ulcer disease in people of interior of Sindh and identification of Helicobacter pylori by histological technique is better than using urease test