Effect of ACE inhibitors on cisplatin-induced nephrotoxicity in rats

ABSTRACT

The effects of captopril and enalapril on cisplatin-induced nephrotoxicity in rats were evaluated. Aqueous solution of either captopril or enalapril was administered orally for 7 days. Cisplatin [15 mg/kg,i.p.] was injected in non-treated rats or with last dose of either captopril or enalapril30 hrs before animal sacrificing. Captopril failed to alter serum urea and creatinine, renal non-protein thiol and malondialdehyde contents. However, enalapril in a high dose [20mg/kg] increased serum creatinine, non-protein thiol. Cisplatin increased serum urea and creatinine levels, renal non-protein thiol and malondialdehyde content. Pretreatment with captopril decrease the effects of cisplatin on serum urea, renal RNA and DNA and. non-protein thiol. In contrast, enalapril potentiated the effects of cisplatin. It is concluded that the protective effect of captopril is a function of sulfhydryl group. Further studies are suggested in determining the role of thiol compounds as a basis for cisplatin-induced nephrotoxicity and its prevention