Hypothyroidie et toxicite musculaire des fibrates a propos d'un cas de polymyosite revelatrice

ABSTRACT

Musculo-skeletal symptoms in hypothyroidism are frequent [30… 80%] ranging from myasthenia, hypertrophic myopathy to just motor delay or cramps. These muscular abnormalities may be the major feature of hypothyroidism. But polymyositis is unusual in primary hypothyroidism. Are these manifestations favorised by muscular toxicity of fibrates report the case of 55 year old woman who was entered the hospital for clinical and laboratory features of poly myositis. She was treated for hypercholesterolemia by fenofibrate. The investigation of polymyositis 's aetiology revealed a moderate hypothyroidism associated to the muscular toxicity of fibrates. The authors will discuss the physiopathology of muscular symptoms in hypothyroidism and the associated muscular toxicity of fibrates