Les predispositions hereditaires aux cancers du sein: profils epidemiologique et anatomoclinique de 11 familles dans le centre Tunisien

ABSTRACT

Five to 10% of women with breast cancer have a positive family history of breast cancer [9.1% in our study]. We designed a comparative study to investigate the potential differences of epidemiologic, clinicopathologic profiles between patients with sporadic breast cancer and those with hereditary breast cancer. Eleven case families [of 27 patients living in the central region of Tunisia occured during the period between 1990 to 1995] are included in the study. Compared to sporadic breast cancer patients, those with hereditary breast cancer are characterized by younger ages of the cancer onset [p = 0.04], higher social and economic situations [p = 0.005], lower pregnancy rate and lower tumor size [p = 0.005]. a good knowledge of genetic factors involved in breast cancer may have important consequences in screening high risk individuals from affected families