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Eradication of pseudomonas aeruginosa biofilms by zinc and its influence on the permeation of some antibiotics
Alexandria Journal of Pharmaceutical Sciences. 1998; 12 (2): 69-73
in English | IMEMR | ID: emr-47455
ABSTRACT
Pseudomonas aeruginosa biofilms were prepared on membrane filters incubated at 37C for 10 days. The biofilms were characterized by dense colonization of bacteria as measured by viable counting and scanning electron microscopy. Incubation of formed biofilms with zinc concentrations between 0.03 and 26.25 UM resulted in a gradual decrease [68.2 - 99.95%] in the number of viable cells. Such decrease was accompanied with a gradual eradication of the biofilms as shown by scanning electron micrographs. Ps. aeruginosa biofilms were found to retard the diffusion of gentamicin, neomycin, tobramycin and ofloxacin. Prior treatment of the biofilms with zinc [2.6 and 26.3 muM] resulted in overcoming such retardation. The implication of such result is possible in the treatment of biofilm associated infections was discussed
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Index: IMEMR (Eastern Mediterranean) Main subject: Pseudomonas aeruginosa / Zinc / Anti-Bacterial Agents Language: English Journal: Alex. J. Pharm. Sci. Year: 1998

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Index: IMEMR (Eastern Mediterranean) Main subject: Pseudomonas aeruginosa / Zinc / Anti-Bacterial Agents Language: English Journal: Alex. J. Pharm. Sci. Year: 1998