Synthesis of 2-alkoxy-3cyano-4,6-diarylpyridines as antibacterial agents
Alexandria Journal of Pharmaceutical Sciences. 1998; 12 (2): 83-87
in English
| IMEMR
| ID: emr-47458
ABSTRACT
Two facile synthetic methods were adopted for the preparation of new series of 2-alkoxy-3-cyano-4, 6-diarylpyridines VI-Xa-e. The first involved the reaction of substituted chalcones with malononitrile in sodium alkoxide-alcohol system. The second reacted the arylidene malononitrile XI, XII with the appropriate aryl methyl ketones XIII-XV in sodium alkoxide-alcohol system. The two methods gave good yields of the target compounds VI-Xa-e. Representative examples of the newly synthesized compounds were evaluated for antibacterial activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pyridines
/
Anti-Bacterial Agents
Language:
English
Journal:
Alex. J. Pharm. Sci.
Year:
1998
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