Antiviral activity of flavonoids with a DNA virus [herpes simplex type 1] and RNA virus [vesicular stomatitis virus]

ABSTRACT

Cytotoxicity and antiviral activities of 38 flavones and flavonols were determined. Several general trends were observed, but the lack of consistent structure-activity relationship suggested the need to conduct additional studies under conditions which measure antiviral activity by a single mechanism or at a discrete point in the virus replication cycle. Consistent with this, seven flavonoids that exhibited substantial cytotoxicity and /or antiviral activity were examined for direct viricidal action on isolated virions prior to infection