Inhibition of oncogene activity as a strategy for identifying cancer chemopreventive agents: Novel inhibitors of protein-tryosine kinase

ABSTRACT

Twenty-seven naturally occurring phenolic compounds of diverse chemical structures were tested for their ability to inhibit epidermal growth factor receptor kinase isolated from A431 cells. Two compounds; namely, purpurogallin and gliotoxin, were highly active exhibiting 98.6 and 97.3% inhibition at 100 ug/mL, respectively. At a lower testing concentration [10 ug/mL], both compounds exhibited almost 80% inhibition