Effects of sumpathomimetic anorexigenic agent [fenfluramine] on some hepatic, haematological and thyroid functions in rabbits

ABSTRACT

Fenfluramine is a sympathomimetic-anorexigenic amphetamine derivative. Fentluramine may affect variable body systems during continuous use. No data as regard the influence of fenfluramine on ferrokinetics and hence this necessitates a proper line of investigation. This study was performed on 40 male Rabbits, divided into two groups; group I for studying liver functions,% saturation of transferrin, and some haematological parameters, group II for studying thyroid functions and radio-active 58Fe ferrokinetics. The results had shown that 1. The chemical had led to significant decrease in liver functions and in serum iron. 2. No significant change was shown in the haematological parameters. 3. There was significant decrease in radio-iron in the plasma. 4. There was significant increase in T3 and T4. Thus the drug might have a deleterious effect on ferrokinetics, liver cells and thyroid gland therefore, it should be used cautiously