Effect of P53 antibodies, interleukin-10, platelet derived growth factor and nitric oxide on apoptosis in discoid and systemic lupus erythematosus and systemic sclerosis

ABSTRACT

This study included seventy patients with systemic lupus erythematosus [SLE, twenty-five patients], systemic sclerosis [SSc, twenty-five patients] and discoid lupus erythematosus [DLE, twenty patients]. The study also included fifteen healthy subjects of comparable age as controls. P53 antibodies were detected in 32% of SLE, 20% SSc and 10% of DLE patients, while they were undetectable in sera of the controls. Serum IL-10, PDGF and NO were significantly higher in SLE, SSc and DLE compared with controls [except for PDGF in DLE]. NO and PDGF were significantly higher in SLE than either SSc or DLE patients. Circulating P53 antibodies were significantly correlated with IL-10, PDGF and NO in all studied groups of patients. Only in SLE patients, disease activity score significantly correlated with the studied bioindices except IL-10. From the revealed results, patients with SLE, SSc and DLE had changes in the aforementioned biochemical factors which might had a role in the defective apoptotic process which occurs in these autoimmune diseases