Expression of insulin-like growth factor-I, II and insulin-like growth factor binding protein-3 in bladder carcinoma

ABSTRACT

Insulin-like growth factors I, II [IGF-I, II] and insulin-like growth factor binding protein-3 were estimated in the sera of 22 subjects suffering from bladder carcinoma and 25 subjects selected as a control group by using IRMA kits. Also, histological examination of the surgical specimen of the cancer bladder patients was done. The results showed that all patients had squamous cell carcinoma and were subdivided into grade II [n = 16] and grade III [n = 6]. IGF-I, IGF- II and IGFBp-3 were significantly higher in sera of bladder carcinoma patients compared with the control group. Serum levels of IGF-II were correlated positively with the grading of the bladder cancer, where IGF-II serum levels in grade III carcinoma were significantly higher than that in grade II carcinoma. On the other hand, neither IGF-I nor IGFBp-3 correlated with the grades of tumor