Serum intercellular adhesion molecule-1 and interleukin-10 in asthmatic children

ABSTRACT

The objective of the present study was to investigate serum, intercellular adhesion molecule-I [sICAM-1] and interleukin-10 [IL-10] in asthmatic children in correlation with immunoglobulin E [IgE]. Thirty asthmatic children and ten controls were enrolled. Using enzyme linked immunosorbent assay [ELISA] sIACM-1, IL-10 and total IgE levels were determined during acute attacks, and 2 weeks after remission [stable asthma]. The results of the present study showed that sICAM-1 and total IgE increased significantly in children during acute attacks Vs controls [P<0.05], while IL-10 decreased significantly in children during acute attack Vs controls [P<0.05]. On the other h and, in stable asthma sICAM-1, IL-10, and total IgE all return to levels comparable with controls. IL-10 correlated significantly in a negative manner with sICAM-1 and total IgE levels. While sICAM-1 correlated positively with total IgE levels We can conclude that sICAM-1 might play a remarkable Pathophysiology role in controlling the severity of asthmatic paroxysm, whereas IL-10 is protective against asthma. The present data open the door in the very near future for therapeutic intervention in pediatric asthma using anti-inflammatory agents could act by blocking ICAM-1 molecules and administration of IL-10 as a novel therapy