Synovial fluid interleukin-1 beta in psoriatic arthritis

ABSTRACT

Synovial fluid from the knee joints of 20 psoriatic arthritis patients [8 with polyarthritis and 12 with mono / oligoarthritis] were studied to detect the value of interleukcin-1 beta. ESR and serum C-reactive protein were also measured. Quantitative immunoassay method showed a significant increase of interleukin-1 beta in the synovial fluid of polyarthritis group as compared to mono/oligoarthritis group, while, ESR, C-reactive protein and synovial fluid total protein, acid phosphatase and WBCs showed non significant changes between the two groups. So, the synovial fluid interleukcin-1 beta is one of the parameters which differentiate between the two groups. Synovial fluid interleukin-1 beta showed significant correlation with the number of affected Joints and Joint score and non-significant correlation with ESR and C-reactive protein. Results confirm the role of interleukin-1 beta in the pathogenesis of psoriatic arthritis as well as to select those who will be in need for aggressive and non conventional treatment