Comparison of small dose ketoprofen and ketorolac added to lidocaine during intravenous regional anaesthesia for post operative analgesia

ABSTRACT

Non-steroidal anti-inflammatory drugs have a predominantly peripheral site of action by blocking the local synthesis of prostagl and ins. The aim of this study was to compare and evaluate whether the additional of small dose ketoprofen and ketorolac to lidocaine during intravenous regional anaesthesia [IVRA] would improve the quality of postoperative analgesia. Sixty patients undergoing upper limb IVRA for minor sugery were randomly assigned to three double-blind groups, group A [placebo], group B where 15 mg ketoprofen was mixed with lidocaine 0.5% for IVRA administered i.v. after toumiquet inflation and group C where 5 mg ketorolac was added to the local anesthetic for IVRA. Mean dose of fentanyl consumption intra operatively was significalltly lower [P < 0.05] in groups B and C when compared with group A durationl of post operative analgesic was significantly longer [P 0<005] in group B [14 +/- 11] and group C [15 +/- 10] when compared with group A [1.4 +/- 0 7], but not significant [P < 0.50] between group B and C. Analgesic requirements remained significantly lower in groups B and C when compared with group A but not significant between groups B and C Pain scores were significantly lower in groups B and C when compared with group A, but was not significant between groups B and C We concuoded that 15 mg ketoprofen and 5 mg ketorolac added to lidocaine 0.5% during IVRA improves the quality of intraoperative and postoperative analgesia and ketoprofen was as efficacious as ketorolac