Some hemostatic variables in diabetes mellitus

ABSTRACT

The pathogenesis of diabetic vascular disease remains obscure and elusive to all methods of investigations. Recent evidences suggest involvement of the haemostatic system in the initiation and/or the propagation of vascular lesions. Our study included sixty diabetic patients [21 males and 39 females] and 23 normal controls. Diabetics were divided according to their response to insulin and the presence or absence of vascular complications. At III, plasma fibrinogen level and euglobulin lysis time were estimated. Significant high levels of AT III were found in IDD patients and complicated diabetics. Significant high levels of plasma fibrinogen were found in all diabetic subgroups with insignificant difference between complicated and uncomplicated cases. Similarly significantly prolonged lysis time was found in all cases with insignificant difference between complicated and uncomplicated diabetics. Our data showed evidence of hypercoagulable state, as shown by raised fibrinogen levels and decreased fibrinolytic activity, accompanying the diabetic state from the start regardless of the onset of vascular complications. This may support the suggestion that haemostatic abnormalities could have a possible initivative role in the pathogenesis of diabetic vascular disease