Determination of amiodaron and propafenone through metal complex

ABSTRACT

Amiodarone and propafenone reacted with copper acetate forming drug- copper complexes and the copper content in the complexes was determined either titrimetrically or by atomic absorption spectrophotometry at 324.7 nm. Amiodarone was also estimated via its reaction with mercuric acetate and titration with lead nitrate in the presence of xylenol orange as indicator. On the other h and, propafenone was determined in the base form by precipitating its silver complex and the excess silver was titrated with ammonium thiocyanate solution. The validity of the methods were assessed by applying the st and ard addition technique and the results were compared with those obtained by the reference methods showing a great agreement