Spectrophotometric determination of fluoxetine and sertraline using chloranil2, 3 dichloro-5, 6 dicyanoquinone and iodine

ABSTRACT

Spectrophotometric procedures have been presented for the determination of 2 commonly used antidepressant drugs Fluoxetine [I] and sertraline hydrochloride [II]. The methods have been based mainly on charge transfer complexation reaction of these drugs with either pi acceptors chloranil and 2, 3 dichloro-5, 6-dicyanoquinone [DDQ], or sigma acceptor iodine. The molar combining ratio and the optimum assay conditions were studied. More detailed investigation of the complex formed in chloranil method was made with respect to its composition, association constant Kc Ad, molar absorptivity epsilon lambda AD, and free energy change delta G. The proposed methods were applied successfully to the determination of the cited drugs either in pure or dosage forms with good accuracy and precision