Synthesis and some reactions of 4-aroyl-6-arlypridazine-3- [2H] ones
Egyptian Journal of Chemistry. 1998; 41 (1-6): 175-86
in English
| IMEMR
| ID: emr-47906
ABSTRACT
4-aroyl -6 -p- tolylpyridazine -3 [2H] ones [2a and b] were prepared by the oxidation of the corresponding 4- benzyl derivatives [3a and b] using sodium dichromate in glacial acetic acid. Compounds [2a and b] underwent normal condensation reactions of ketones with hydrazine hydrate and 2,4- dinitrophenyl- hydrazine to give the corresponding hydrazones [5a-c] and with hydroxylamine hydrochloride to give the oximes [5d and e]. 2a and b] reacted with dimethyl sulphate to give 6a and b. The reaction of [2a and b] with formaldehyde in the presence of secondary amines gave the Mannich bases [8a-d]. The pyridazinones [2a and b] underwent a Michael type addition to acrylonitrile to give [9a and b], respectively. The alkaline hydrolysis of [9b] affected complete cleavage of the cyanoethyl group yielding the aroylpyridazinone [2b]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Benzyl Compounds
/
Acetates
Language:
English
Journal:
Egypt. J. Chem.
Year:
1998
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