Synthesis and antitumor properties of some 9-benzylpurine derivatives

ABSTRACT

During the past few years numerous synthetic purines have been claimed to have multitude of useful biological and pharmacological activities. For example, the antitumour [1-3] and antiviral [4,5]properties of many purine derivatives have been reported. Also, some alkoxy/aryloxycaffiene derivatives have been reported to exhibit cytostatic action against tumour cells in tissue culture [6]. Moreover, 6-methoxypurine has been proved to show activity at 250 and 125 mg/kg versus L 1210 leukaemia [7] Therefore, the interest in the present work was directed for synthesizing some newer purine derivatives with the target to evaluate their potential antitumour properties