new type of piperidine derivative for analgesic activity

ABSTRACT

A new chemically synthesized piperidine derivative i.e. 1-methyl-1 [4-chloro] phenacyl-4-hydroxy piperidinium bromide was tested for analygesic activity in intact albino mice by tail flick latency in tail immersion method [Di Stasi et al., 1988]. The compound was administered orally in the doses of 50 mg/kg. Pethidine HCI 50 mg/kg was used as a reference drug. Control animals received only the vehicle. The result indicates that this compound exhibits highly significant analgesic activity